[ Instrument Network Instrument Development ] Recently, Yang Liangbao, Researcher of Bioelectronics Technology Laboratory, Center for Medical Physics and Technology, proposed an effective method for constructing long-period, high-stability surface-enhanced Raman spectroscopy three-dimensional hotspot matrix using glycerol. The related results are published in the RSC database TOP journal Chemical Communications under the title of Long-period and High-stability Three-dimensional Surface-enhanced Raman Scattering Hotspot Matrix.
Schematic diagram of three-dimensional hot spot matrix in glycerin system and water system
In the early stage, Yang Liangbao's research team developed a dynamic surface-enhanced Raman spectroscopy (D-SERS) method by solvent evaporation to induce self-assembly of nanoparticles. The three-dimensional hotspot matrix formed during solution evaporation was used to achieve a highly sensitive response of SERS. . However, due to the rapid evaporation rate of the aqueous solution, the three-dimensional hot spot has a short existence time and poor stability. Therefore, in response to these problems, Yang Liangbao and other researchers have proposed a method for constructing long-period, high-stability surface-enhanced Raman three-dimensional hotspot matrices using glycerol. The method increases the number of three-dimensional Ag NPs hotspot matrices, greatly improves the sensitivity of SERS detection, and achieves highly sensitive and stable detection of nanobiomolecule marine toxins, pesticide residues, drugs, and the like. The long-period and high-stability three-dimensional hotspots constructed have reduced the occurrence of accidental factors caused by the short time of the water system hotspots, making the experiment more operable, in the field of actual crime scene analysis, medical diagnosis, food safety, etc. The application prospects are broader.
The above research work has won the national science and technology major project "Key technology for constructing high-density hot spot SERS probe chip based on aptamer" and Anhui Science and Technology Police Project "multi-channel portable drug on-site detection box", "Hair in Drugs Qualcomm" Funding for the development of rapid detection systems.
(Original title: Medical Physics Center has made new breakthroughs in the construction of long-period, high-stability surface-enhanced Raman spectroscopy three-dimensional hotspot matrix)
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