China's granulator market will show a good trend

Granulation is a process that uses powder agglomeration to increase the size of the particles and is an important operating unit in the formulation process. At present, various granulation techniques have been developed, such as dry granulation, wet granulation (reverse wet granulation, reverse wet granulation, steam granulation, moisture activated dry granulation), thermal bonding granulation technology , melt granulation, freeze granulation, foam granulation, and the like.

Understanding and being able to control granulation is critical to producing high quality drugs, and the granulators that carry the above technology will provide superior process reproducibility and better process control for pharmaceutical production, resulting in specific A uniform material of particle size.

For example, a centrifugal granulator, a centrifugal granulator can be centrifuged to prepare a pellet core, a centrifugal drug, and a centrifugal coating. The pellet core prepared by centrifugation mainly comprises a pure auxiliary pellet core such as a sucrose pellet core, a microcrystalline cellulose pellet core, a pellet core of different types and different proportions, or a pellet core of a raw material or a pellet core mixed with a raw material.

Centrifugal medicine is mainly used to mix the raw materials and auxiliary materials, and according to the spraying speed and the wet state of the pellet core, the dusting speed is set and the medicine is centrifuged. The centrifugation coating is a coating of the pellets, which may be a coating in a solid form or in a liquid form, generally as a barrier between the layers of the drug or between the layers.

Compared with the general granulator, the centrifugal granulated particles have higher hardness, better fluidity and more uniform particle size distribution. In addition, centrifugal granulators require less performance for excipients, such as water retention, and a wider range of excipients.

Another example is the dry granulator, which can directly form the powder raw material into a granular product that meets the user's requirements without any intermediates and additives. After granulation, the product has uniform particle size and a significant increase in bulk density, and Improved liquidity.

“In the dust environment, the dry granulator can reduce the dust flying in the production process, reduce the waste of powder, and facilitate storage and transportation. In addition, the machine can control the solubility, porosity and Specific surface area, etc., can be directly used for tableting or filling capsules." Granulator * said.

The author has learned that at present, the dry granulator process can replace the pipeline of wet granulation, which can save manpower, material resources, financial resources, energy saving and environmental protection, and produce granular products that meet user requirements.

In the past few years, China's pharmaceutical granulation technology and process level have been significantly improved, advanced granulation methods and granulation equipment have always attracted the eager attention of the pharmaceutical industry, and promote pharmaceutical companies to conduct research and development.

According to the analysis of relevant research reports, the market development of international granulators has shown a steady upward trend. It is expected that the market of granulators in China will show a good trend from 2018 to 2022.

According to the industry, after years of production technology introduction and technological innovation, granulator equipment enterprises have gradually shortened the gap with advanced granulators. Together with China's advantages in labor prices, the export of domestic granulators is The share in the world market has increased significantly.

"In recent years, China's granulators have not only made great progress in the field of terminals, but also made great breakthroughs in the field of high-quality granulators. In addition, with the rapid development of the pharmaceutical industry, the demand for granulators continues to increase. The equipment is becoming more and more large-scale, and the user's stability and energy-saving requirements for the granulator are getting higher and higher." Insiders analyzed that for this situation, China's granulator enterprises also need to combine granulation technology and technology. In-depth understanding of the physical and chemical properties of drugs, and the main line of transformation and upgrading, adhere to the development path of high quality, innovation, energy conservation and environmental protection.

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